P.099 Integrating DNA methylation profiling in brain tumour diagnosis directly changes patient oncological care
نویسندگان
چکیده
منابع مشابه
Epigenomic profiling reveals DNA-methylation changes associated with major psychosis.
Epigenetic misregulation is consistent with various non-Mendelian features of schizophrenia and bipolar disorder. To date, however, few studies have investigated the role of DNA methylation in major psychosis, and none have taken a genome-wide epigenomic approach. In this study we used CpG-island microarrays to identify DNA-methylation changes in the frontal cortex and germline associated with ...
متن کاملDNA Methylation Profiling Identifies CG Methylation Clusters in Arabidopsis Genes
Cytosine DNA methylation in vertebrates is widespread, but methylation in plants is found almost exclusively at transposable elements and repetitive DNA. Within regions of methylation, methylcytosines are typically found in CG, CNG, and asymmetric contexts. CG sites are maintained by a plant homolog of mammalian Dnmt1 acting on hemi-methylated DNA after replication. Methylation of CNG and asymm...
متن کاملGamma Irradiation Does Not Induce Detectable Changes in DNA Methylation Directly following Exposure of Human Cells
Environmental chemicals and radiation have often been implicated in producing alterations of the epigenome thus potentially contributing to cancer and other diseases. Ionizing radiation, released during accidents at nuclear power plants or after atomic bomb explosions, is a potentially serious health threat for the exposed human population. This type of high-energy radiation causes DNA damage i...
متن کاملUVB irradiation does not directly induce detectable changes of DNA methylation in human keratinocytes
Unprotected exposure to UVB radiation from the sun and the resulting DNA damage are thought to be responsible for physiological changes in the skin and for a variety of skin cancers, including basal cell and squamous cell carcinoma and malignant melanoma. Although the mutagenic effects of UVB have been well documented and studied mechanistically, there is only limited information as to whether ...
متن کاملImaging, Diagnosis, Prognosis EFEMP1 as a Novel DNA Methylation Marker for Prostate Cancer: Array-Based DNA Methylation and Expression Profiling
Purpose: Abnormal DNA methylation is associated with many human cancers. The aim of the present study was to identify novel methylationmarkers in prostate cancer (PCa) bymicroarray analysis and to test whether these markers could discriminate normal and PCa cells. Experimental Design: Microarray-based DNA methylation and gene expression profiling was carried out using a panel of PCa cell lines ...
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ژورنال
عنوان ژورنال: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
سال: 2019
ISSN: 0317-1671,2057-0155
DOI: 10.1017/cjn.2019.194